record_type,parameter,value,unit,evidence_class,formula_or_note
input,initial_feed_volume,500,L,synthetic process basis,Volume before concentration
input,diafiltration_retentate_volume,100,L,synthetic process basis,Constant during diafiltration
input,initial_impurity_concentration,120,mmol/L,synthetic process basis,At start of diafiltration
input,target_impurity_concentration,1,mmol/L,synthetic specification,End-of-diafiltration target
input,incoming_buffer_impurity_concentration,0,mmol/L,synthetic process basis,General model accepts nonzero values
input,impurity_sieving_coefficient,0.95,dimensionless,synthetic screening assumption,Replace with paired permeate and retentate measurements
input,product_sieving_coefficient_UF,0.0015,dimensionless,synthetic screening assumption,Concentration phase
input,product_sieving_coefficient_DF,0.0015,dimensionless,synthetic screening assumption,Diafiltration phase
input,UF_design_flux,25,L/(m2*h),synthetic screening assumption,Phase-specific constant flux
input,DF_design_flux,25,L/(m2*h),synthetic screening assumption,Phase-specific constant flux
input,maximum_process_time,6,h,synthetic specification,Excludes non-processing allowances
input,selected_membrane_area,6.5,m2,synthetic equipment choice,Available installed area
result,concentration_factor,5,dimensionless,calculated,500/100
result,required_diavolumes,5.039464992,dimensionless,calculated,ln(120/1)/0.95
result,diafiltration_buffer_volume,503.9464992,L,calculated,ND*100
result,total_permeate_volume,903.9464992,L,calculated,(500-100)+ND*100
result,UF_product_retention,0.997588755,fraction,calculated,5^(-0.0015)
result,DF_product_retention,0.992469301,fraction,calculated,exp(-0.0015*ND)
result,combined_product_yield,0.990076215,fraction,calculated,UF retention*DF retention
result,minimum_membrane_area,6.026309995,m2,calculated,"[(400/25)+(503.9464992/25)]/6"
result,process_time_at_selected_area,5.562747688,h,calculated,"[(400/25)+(503.9464992/25)]/6.5"