What is a bioprocess digital twin in Acatian?

An Acatian digital twin is a versioned engineering model that links the process graph, mass and energy balances, dynamic states, equipment and schedule states, measured data, assumptions, uncertainty and review evidence for a defined decision.

Does a digital twin require live plant data?

Not always. A design twin can operate from authorized engineering and experimental data. An operational twin requires governed plant connectivity, tag mapping, time alignment, data-quality rules, calibration, monitoring and a defined response when the model and plant diverge.

Can Acatian autonomously control a production plant?

No public Acatian workflow should be treated as autonomous plant control. Closed-loop control requires site-approved PLC or DCS integration, interlocks, cybersecurity review, validated models and qualified operational ownership.

Bioprocess digital twin software

Keep the plant, the model, and the evidence synchronized.

Acatian links the process graph, dynamic states, equipment and schedule states, measured production data, assumptions, uncertainty, model versions, and review evidence around one defined engineering decision.

Define a digital-twin pilot See validation workflow

A governed twin shows what is measured, inferred, assumed, calibrated, and still missing.

Process graphDynamic statesPlant dataAsset statesDecision evidence

01 · Context

Decision and envelope

Define the question, process range, users, outputs, tolerance, update frequency, and excluded uses before connecting data.

02 · Model

Mechanistic state

Connect components, reactions, ODE/PDE states, equipment constraints, schedules, costs, impacts, and uncertainty.

03 · Data

Measured plant state

Map historian tags, batches, assays, recipes, alarms, maintenance, quality records, units, timestamps, and ownership.

04 · Governance

Fit for decision

Track residuals, drift, calibration range, versions, approvals, missing evidence, and the response to model-plant divergence.

Twin levelWhat Acatian representsWhat must be proven

Design twinFlowsheet, balances, equipment, schedule, TEA/LCA and scenariosAuthorized design basis, reconciliation and sensitivity coverage

Calibrated twinParameters fitted to identified batches and operating conditionsResiduals, independent validation data and validity domain

Operational twinTime-aligned plant state, prediction, monitoring and alertsSecure connectivity, data quality, drift handling and qualified response

Closed-loop controlNot a public Acatian software claimSite-approved DCS/PLC integration, interlocks, validation and operational ownership

NREL biochemical conversion pilot plant with connected stainless-steel process vessels and utilities — **Plant context**Assets, utilities, cleaning, rooms, schedules, material flows, and control boundaries remain visible.

Acatian editable flowsheet linked to digital twin data and model history — **Model context**Every observation and recommendation resolves to equipment, streams, parameters, sources, and a versioned model change.