Is the browser CFD view a validated three-dimensional solver?

No. The browser view is an interactive engineering screen for geometry, boundary conditions and transport-risk review. A validated CFD result requires an external solver, verified mesh, material and turbulence models, convergence evidence and experimental validation.

Which bioreactor boundary conditions can Acatian define?

Acatian structures gas and liquid inlets, sparger location, feed composition, walls and baffles, headspace pressure outlet, impeller rotating zones, heat transfer, oxygen and nutrient sources and sinks, and time-dependent cell uptake.

Which CFD results should be reviewed for scale-up?

Typical outputs include velocity, gas holdup, dissolved oxygen and nutrient fields, mixing and circulation time, shear exposure, dead zones, mass-transfer performance, residuals, mesh independence and comparison with tracer or probe data.

Bioreactor CFD simulation

Define the real reactor before interpreting a fluid field.

Structure vessel geometry, baffles, impellers, sparger, gas and liquid feeds, headspace, material properties, cell uptake, heat transfer, turbulence, multiphase transport, and time-dependent boundary conditions.

Scope a CFD case Read scale-up guide

The reactor geometry, operating conditions, numerical model, and validation evidence define the value of a CFD result.

GeometryMeshPhysicsBoundariesConvergenceValidationScale-up decision

Geometry

Reactor internals

Liquid height, headspace, baffles, shafts, impeller type and clearance, sparger holes, probes, dip tubes, feed ports, and coils.

Physics

Transport model

Liquid and gas phases, rheology, turbulence, bubble size, drag, oxygen transfer, heat, scalar transport, and biological source terms.

Numerics

Solver evidence

Mesh quality and independence, rotating-zone method, time step, discretization, residuals, conservation, monitoring points, and run history.

Validation

Measured comparison

Torque or power, gas holdup, mixing time, kLa, probe maps, tracer curves, oxygen response, and uncertainty over the operating envelope.

Boundary or zoneModel definitionEngineering consequence

Gas inlet + spargerGas rate, composition, bubble model, hole layout and source locationGas holdup, plume, interfacial area, kLa and oxygen source distribution

Liquid feed inletFlow, composition, momentum, temperature and time profileLocal glucose, glutamine, pH, osmolality and feed-exposure risk

Impeller zoneMRF, sliding mesh or resolved rotation with speed and directionCirculation, power, shear exposure, gas dispersion and blend time

Cells and chemistrySpatial oxygen and nutrient sinks, heat and metabolite source termsLate-batch gradients, limitation zones and coupling to dynamic kinetics

Interactive engineering screenGeometry and boundary-condition review · time-dependent screening · scenario comparison · external case packaging

Validated external CFDQualified solver · verified mesh · convergence and conservation evidence · experimental comparison · documented limitations