Public reference models · no account required

Process models you can inspect, reproduce and challenge.

Explore a 2,000 L mAb upstream screening model from media preparation through harvest, then download its inputs, results and checks. A 100 m³ fermentation model is also available. Public models demonstrate software execution and traceability, not customer calibration or GMP validation.

Inspect the public model Download methodology

Catalog version: 2.0.0
Solver: RK4 · 3,360 steps
Reported time points: 169
Balance residual: 2.67 × 10⁻⁷%
Acceptance: 7 / 7 passed
Model state: Screening · 2 models

00 · Workspace screenshots

Preview the workspace and download model data.

These screenshots illustrate the flowsheet, plant overview and TEA/LCA workspace. The reference files below define the separately calculated numerical benchmark. Explore its trajectory in the chart or download inputs, results and checks. Sign in to edit a model copy.

Acatian application screenshot illustrating the flowsheet editor; reference inputs and results are provided separately — **Flowsheet screenshot**Shows equipment, material and utility streams, process sections, open ports and the next engineering task. Object parameters are available in the editable workspace.

01 · Process families

Download mAb and fermentation screening models.

Every package contains declared inputs and intervals, complete trajectories, balance checks, sensitivities, comparison data, streams, finite-capacity scheduling and checksummed artifacts.

AC-REF-FERM-FB-001 · SCREENING

Industrial fermentation

100 m³ microbial fed-batch with explicit biomass, substrate, product, oxygen, feed and working-volume balances.

Mode: Fed-batch
Trajectory: 169 points
Checks: 7 / 7

AC-REF-MAB-FB-001 · SCREENING

mAb biopharma

2,000 L CHO fed-batch with dynamic cell, substrate, product, dissolved-oxygen, lactate and ammonium states.

Mode: Fed-batch
Trajectory: 169 points
Checks: 7 / 7

Final titer0.981 g/Lreactor inventory

Batch product1.726 kgbefore DSP recovery

Peak VCD12.3310⁶ cells/mL

Max ammonia1.858 mM2.0 mM boundary

Max lactate1.976 g/L2.0 g/L boundary

02 · Model scope

One connected upstream benchmark.

Defined boundary: raw media through reactor harvest. Downstream operations are represented as open handoff boundaries and are not used to claim final drug-product yield.

T-101Media preparation1,440 L initial charge

F-103Sterile filtration0.2 µm boundary

BR-201Seed expansionsynthetic inoculum

BR-3012,000 L fed-batch336 h dynamic run

CF-401Harvest handoffopen DSP boundary

INBasal medium

INConcentrated feed

INGas transfer via kLa

OUTHarvest broth

OPENOff-gas composition

03 · Executable result

Inspect the complete 336-hour trajectory.

04 · Acceptance

Passes are machine-readable; gaps remain visible.

Each criterion has a threshold, an observed value and a review status.

05 · Reproducibility package

Download inputs, trajectories, checks and sensitivities.

Every generated artifact is listed with a SHA-256 checksum in the manifest.

InputsValues, intervals, units and evidence classCSV Dynamic profile169-point state trajectoryCSV Sensitivity18 low/base/high solver runsCSV AcceptanceThreshold, observation and statusCSV ComparisonObserved values, screening envelope and statusCSV Stream tableInlets, process outputs and open boundariesCSV ScheduleResource occupancy and turnaround basisCSV SummaryMachine-readable headline resultsJSON ManifestVersion and SHA-256 integrity checksJSON

What this proves

Executable, traceable software behavior.

The same inputs regenerate the published trajectory.
The numerical component balance meets its stated tolerance.
Physical screening boundaries are evaluated explicitly.
Parameter variation produces inspectable sensitivity outputs.
Artifacts can be independently checked against the manifest.

What remains to be proven

Industrial predictive validity.

Calibration against customer-owned bioreactor and assay data.
Independent comparison with an approved reference model.
Validated downstream recovery and product-quality models.
Site-specific equipment, schedule, utilities, TEA and LCA evidence.
Qualified review for GMP, safety and investment decisions.