Process basis
Components, reactions, yields, kinetics, feeds, harvest logic, recycle, cleaning, operating mode, working volume, and scale.
Bioprocess simulation software
Bioprocess simulation software for complete biomanufacturing processes.
Acatian connects process flowsheets, component balances, reactions, ODE/PDE dynamics, operating modes, equipment duties, physical limits, scheduling, uncertainty, and economics without separating the model from its evidence.
BatchFed-batchPerfusionContinuousHybrid trains
Engineering model
Mass and energy balances, equipment duty, ODE/PDE states, oxygen transfer, heat removal, physical boundaries, and uncertainty.
Review outputs
Throughput, bottlenecks, sensitivities, cost, environmental burden, model validity, missing evidence, and detailed exports.
Selection map
Choose the modelling layer that matches the decision.
No single simulator is automatically best for every question. Define the required physical depth, time scale, facility scope, evidence and review path before comparing features.Whole-process flowsheet
Use for component flows, unit operations, equipment duty and plant-wide balance closure. A flowsheet alone may not resolve reactor kinetics or spatial transport.
Mechanistic reactor model
Use for growth, substrate, product, metabolites, oxygen demand and heat generation over time. It does not automatically represent the complete factory.
CFD and transport
Use for spatial flow, gas hold-up, mixing and transfer fields. Decision use requires a qualified solver, mesh and convergence evidence plus experimental validation.
Discrete-event scheduling
Use for finite equipment, rooms, operators, utilities, CIP/SIP, queues and campaigns. It complements rather than replaces the physical process balance.
TEA and LCA
Use for cost, resource and environmental consequences. Results are only as defensible as the declared functional unit, system boundary, year and evidence basis.
Operational digital twin
Use when a governed model is compared with plant data in operation. This requires controlled data connections, monitoring, ownership and an explicit response workflow.
QuestionAcatian outputRequired inputs
Can the process scale?Operating envelope and scale-up gapsKinetics, kLa, mixing, heat, rheology, geometry
Does the route close?Component balance and residual diagnosticsStream assays, yields, hold-up, losses, recycle
Which scenario wins?Before/after comparison with sensitivitiesRanges, source ownership, validation criteria
Engineering definition
What is bioprocess simulation software?
It represents biological conversion, material and energy flows, equipment behaviour and time-dependent operations in one quantitative process model.Why engineers use it
Test whether a process route closes, scales, fits available assets and meets throughput, cost and environmental targets before committing plant time or capital.
What Acatian connects
The flowsheet, equations, evidence, uncertainty, facility schedule and decision outputs stay attached to the same version, so assumptions and scenario differences remain inspectable.
Which decisions it supports
Evaluate scale-up feasibility, equipment fit, annual capacity, production mode, bottlenecks, COGS, environmental impact and the evidence still needed for review.