Acatian Engineering Brief

Original technical notes for bioprocess modelling and plant decisions.

Focused methods, executable benchmarks and validation questions for engineers working across process development, MSAT, manufacturing, facility design, TEA and LCA.

Acatian EngineeringUpdated 13 August 2026Open technical library

Every note links engineering equations to evidence requirements, model limits and a practical decision.

Dynamics + scale-up

Build the reactor model without losing the whole process.

Use time-resolved states and physical constraints, then propagate the result into downstream load, scheduling and economics.

New · 16 minFed-batch process simulationState balances, feed events, oxygen and heat limits, downstream load and validation.New · 15 minCHO cell culture process modelGrowth, viability, mAb productivity, metabolites, scale-up and COGS.14 min guideBioreactor scale-upOTR, mixing, shear, heat removal, geometry and uncertainty.

Facility + operations

Translate the process into manufacturing reality.

Model reusable equipment, rooms, utilities, people, cleaning and customer variants instead of treating annual utilization as a fixed input.

New · role guideMSAT process modelling toolsTech transfer, site fit, manufacturing evidence and controlled change.New · role guideCDMO process developmentCustomer intake, facility fit, campaigns, costs and delivery risk.Capacity guideFinite-capacity schedulingEquipment states, shared resources, queues, cleaning and campaigns.

Validation + reproducibility

Make technical claims independently inspectable.

Reference implementation

AX-REF-MAB-FB-001 publishes versioned inputs, 169 dynamic states, sensitivities, numerical balance closure, acceptance criteria and SHA-256 checksums. It demonstrates reproducible software behavior without claiming customer-specific industrial validation.

Inspect the benchmark

Model validation

Define context of use, independent evidence, acceptance tolerances, residual analysis, uncertainty, extrapolation limits, maturity and technical ownership before calling a model decision-ready.

Read the validation guide

Mass-balance discipline

Track every component, reaction, accumulation term, recycle, purge, sample and loss on one declared basis. Report per-unit residuals so plant-wide closure cannot hide local errors.

Build the mass balance

Reference implementation

Model validation

Mass-balance discipline

Receive one useful technical note.